Abstract
To assess the effect of dexmedetomidine on myocardial ischemia reperfusion injury in vivo aged rat heart. 40 healthy male, 20month aged, 350–400g Sprague-Dawley rats. Rats were divided into four groups randomly(n=10): group of ischemic preconditioning(IP group), group of Sham(CS group), group of dexmedetomidine(DP group), Ischemia-reperfusion injury group(IR group). The date of HR and ±dp/dtmax were detected before and after the occur of ischemia reperfusion. Superoxide dismutase (SOD) and malondialdehyde (MDA) activity were recorded; myocardial infarct size was calculated at the end of reperfusion. HR in each group decreased after thoracotomy. Compared with CS group, the HR in IR group reduced significantly (P<0.05). After given dexmedetomidine, HR in the DP group began to decrease significantly. Left heart function in IR group compared with the CS group showed that a statistically reduce of left ventricular function happened in IR group. ±dp/dtmax of the IR groups compared with the CS group were increased. SOD activity reduced and MDA in myocardial tissue homogenates increased in IR group (P<0.05); SOD activity in DP group compared with IR group deduced, MDA increased (P<0.05). Dexmedetomidine preconditioning can effectively reduce ischemia reperfusion injury of the aged rat in vivo, have a protective effect on aged rat heart.
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