Abstract
Susceptible (S) Aedes aegypti (L.) larvae exhibited a higher respiratory rate than those of a DDT-resistant (R) strain. whereas various concentrations of DDT increased the rate of oxygen consumption of R larvae, low concentrations of the insecticide increased oxygen uptake of the S strain and high concentrations decreased it. when the temperature was increased from 28°C. to 37.1°C., the oxygen consumption of the R larvae was higher. As compared with intact larvae, homogenates exhibited a prolonged lag period in their oxygen uptake, after which oxygen was consumed at a greatly enhanced rate, which was higher in the S larvae. The addition of the soluble fraction of the cell increased the oxygen uptake of mitochondria even when present in a concentration of only one-fifth that of the total homogenate. Although DDT inhibited oxidative phosphorylation in both strains, the degree of in hibition was greater in the S strain. This inhibition Vasdue largely to the reduction in the esterification of inorganic phosphate, the oxygen uptake being only slightly affected.
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