Abstract
Administration of cyclosporin A (CyA) to mice prior to infection and at weekly intervals during the infection with Giardia muris resulted in an increase in cyst output and a delay of the elimination phase of the infection. A short term treatment (4 days) of infected mice with CyA induced a significantly higher cyst release after treatment. CyA did not affect the ability of immune mice to resist reinfection. Our findings indicate that CyA has compromised immunological control of the primary Giardia infection, but not the ability of the immune host to resist reinfection. We propose that the use of immunosuppressive drugs may be a contributing factor in transmission of giardiasis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The American journal of tropical medicine and hygiene
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
