Abstract
Background and objective: The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. Methods: We searched the following databases up until January 2018: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and evaluated for quality of the studies in accordance with the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Results: Eighteen articles (21 studies) that comprised a total of 1,604 individuals were finally included in the meta-analysis. Curcumin intake significantly reduced body mass index (BMI) (SMD −0.37; 95% CI, −0.61, −0.13; P < 0.01), weight (SMD −0.23; 95% CI, −0.39, −0.06; P < 0.01), waist-circumference (WC) (SMD −0.25; 95% CI, −0.44, −0.05; P = 0.01), leptin levels (SMD −0.97; 95% CI, −1.18, −0.75; P < 0.001) and increased adiponectin levels (SMD 1.05; 95% CI, 0.23, 1.87; P = 0.01). We found no significant effect of curcumin intake on hip ratio (HR) (SMD −0.17; 95% CI, −0.42, 0.08; P = 0.18). Conclusions: Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR.
Highlights
Metabolic syndrome (MetS), obesity, and type 2 diabetes mellitus (T2DM) are rapidly increasing in prevalence globally, possibly related to poor lifestyle habits, a high calorie diet, low physical activity, and smoking (Ewang-Emukowhate et al, 2014)
randomized controlled trials (RCTs) retrieved that have investigated the association between curcumin intake and body composition using the following Medical Subject Headings (MeSH) and search terms: patients (“obese” OR “overweight” OR “T2DM” OR “hyperlipidemic” OR “non-alcoholic fatty liver disease (NAFLD)” OR “MetS”), intervention (“curcumin” OR “turmeric” OR “curcuminoids” AND “intake” OR “supplementation”), and outcomes (“body mass index [BMI]” OR “body weight” OR “waist-circumference [WC]” OR “hip ratio [HR]”OR “leptin” OR “adiponectin”)
Administered curcumin in trials included in the present meta-analysis was as powder, or extract
Summary
Metabolic syndrome (MetS), obesity, and type 2 diabetes mellitus (T2DM) are rapidly increasing in prevalence globally, possibly related to poor lifestyle habits, a high calorie diet, low physical activity, and smoking (Ewang-Emukowhate et al, 2014). In parallel with the obesity pandemic, MetS is an increasing in prevalence, and affects approximately 20% of people in the world (Ofori-Asenso et al, 2017) Both MetS and overweight are associated with elevated risk of mortality, metabolic disturbances, T2DM, vascular complications including atherosclerotic disease and coronary heart disease (CHD) (Phillips, 2013; Katsiki et al, 2014; Santilli et al, 2017). Some other studies have documented a significant effect of curcumin intake on indicators of body composition (Chuengsamarn et al, 2012; Panahi et al, 2017a) Anthropometric parameters such as BMI, weight, waist and hip circumference, total body fat, and parameters of oxidative stress were not affected following the intake of curcumin at a dosage of 1 g/day in obese people (Mohammadi et al, 2013) and 1 g/day in people with MetS (Ghazimoradi et al, 2017). The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders
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