Abstract
BackgroundIsoflavones are naturally occurring plant chemicals belonging to the “phytoestrogen” class. The aim of the present study was to examine the effects of isoflavones obtained from Cordyceps sinensis (CSIF) on development of estrogen deficiency-induced osteoporosis in ovariectomized rats.MethodsAfter the rats were treated orally with CSIF, serum alkaline phosphatase (ALP), tartarate resistant acid phosphatase (TRAP), serum osteocalcin (OC), homocysteine (HCY), C-terminal crosslinked telopeptides of collagen type I (CTX), estradiol and interferonγ (IFN-γ) level were examined. At the same time, the urine calcium, plasma calcium, plasma phosphorus and the mass of uterus, thymus and body were also examined.ResultsThe beneficial effects of CSIF on improvement of osteoporosis in rats were attributable mainly to decrease ALP activity, TRAP activity, CTX level and IFN-γ level. At the same time, CSIF also increase the OC and estradiol level in ovariectomized osteopenic rats. The histological examination clearly showed that dietary CSIF can prevent bone loss caused by estrogen deficiency.ConclusionThe significant estrogenic activity of CSIF demonstrated that CSIF has significant estrogenic effects in OVX rats.
Highlights
Isoflavones are naturally occurring plant chemicals belonging to the “phytoestrogen” class
We propose the effects of isoflavones, which are naturally occurring plant chemicals belonging to the “phytoestrogen” class, obtained from Cordyceps sinensis on development of estrogen deficiencyinduced osteoporosis in ovariectomized rats
This study has shown for the first time that the oral administration of CSIF has significant estrogenic effects in OVX rats, including dose-dependently increasing uterine weight, restoring the uterine structure
Summary
Isoflavones are naturally occurring plant chemicals belonging to the “phytoestrogen” class. The aim of the present study was to examine the effects of isoflavones obtained from Cordyceps sinensis (CSIF) on development of estrogen deficiency-induced osteoporosis in ovariectomized rats. Many research groups have reported that isoflavones were associated with human health benefits such as decreased risks of various cancers, heart disease, cardiovascular disease, and increased antioxidative effects [12,13,14]. Isoflavones are naturally occurring plant chemicals belonging to the “phytoestrogen” class [15]. These compounds have structures similar to mammalian estrogens and display both estrogenic and anti-estrogenic effects [16]
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