Abstract
In this work, we studied the effects of copper incorporation in the composition of bioactive glass. Three different glass compositions were synthesized with 0, 3, and 6 mol% of copper addition. X-Ray Diffraction (XRD) patterns confirmed that an amorphous microstructure was obtained for all three glass compositions. Results from Differential Thermal Analysis (DTA) showed that the copper addition in the glass lowers the glass transition temperature, from 646°C to 590°C when added at 6 mol%. X-ray Photoelectron (XPS) survey and high-resolution scans were performed to study the structural effects of copper addition in the glass. Results indicated that the incorporation of copper changes the ratio of bridging to non-birding oxygens in the structure. Glasses were further analyzed for their structure with Nuclear Magnetic Resonance (NMR) spectroscopy, which indicated that copper acts as a network modifier in the glass composition and copper-containing glasses show a less connected microstructure. Antibacterial efficacy of the glasses was analyzed against E. coli and S. epidermis. Copper-containing glasses showed a significantly higher inhibition zone compared to control glass. The glass with 6 mol% copper, exhibited inhibition zones of 9 and 16mm against E. coli and S. epidermis bacteria, respectively.
Highlights
Bioglass®, known as 45S5 glass, was first discovered by professor Larry Hench in the late 1960s in order to develop a material to fill bone voids without being rejected by the body[1]
The diversity of their applications comes from the glass composition, and how it can be modified by the incorporation of new elements and changing the glass structure[2]
We aim to investigate any changes occurring in the antibacterial efficacy of the glass as a result of copper addition
Summary
Bioglass®, known as 45S5 glass, was first discovered by professor Larry Hench in the late 1960s in order to develop a material to fill bone voids without being rejected by the body[1]. The initial 45S5 Bioglass® that was introduced by Hench was a silicate-based glass with a composition of 45SiO2-24.5Na2O-24.5CaO-6P2O5 in weight percent[2]. Studies on this composition showed its capacity to form a chemical bond with living tissue[3]. The bioactive glasses have been used in dental applications, applied as bioactive coatings on the surface of metal implants, used as bioactive components of composites and have been made into synthetic bone scaffolds[2,3, 6,7,8]. The diversity of their applications comes from the glass composition, and how it can be modified by the incorporation of new elements and changing the glass structure[2]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
