Abstract
Ribs from 6 oophorectomized and 4 17 beta-estradiol-supplemented spayed, 4-year-old Beagle dams were subjected to histomorphometric analyses to determine what effects continuous estradiol treatment of 9 months duration had on the Basic Multicellular Unit (BMU) of cortical bone remodeling. The findings of this study suggest that 17 beta-estradiol has a two-step mode of action. First, this estrogen directly suppresses the formation of new BMUs. Secondly, it causes uncoupling of the Resorption/Formation (R/F) mechanism within each BMU, together with the creation of an approximate 1:1 balance between bone resorption and bone formation. This balance is probably responsible for the preservation of cortical bone mass seen to occur with continuous estrogen replacement therapy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
