Abstract
Methylphenidate, (MPH), is commonly prescribed for attention deficit/hyperactivity disorder (ADHD). It is similar to cocaine in that it inhibits the dopamine transporter to elevate extracellular dopamine levels and has reinforcing effects. As ADHD diagnoses have increased, MPH abuse has increased as well. There is evidence that DA antagonists such as Clozapine may be effective in mitigating cocaine abuse. Therefore, it is hypothesized that Clozapine will inhibit the rewarding effects of MPH in a conditioned place preference (CPP) paradigm. The data showed that both MPH and Clozapine treated groups had a significant aversion to the drug-paired compartment. Because MPH produced a conditioned aversion, the effect of Clozapine on the rewarding effects of MPH remains to be elucidated. Future studies using lower doses of MPH, as well as those analyzing dopamine levels in the striatum and prefrontal cortex would provide evidence of the effect of Clozapine on mesolimbic dopamine systems.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
