The effects of clovoxamine on sleep of normal volunteers: A double‐blind placebo‐controlled study

Abstract

AbstractIn a double‐blind placebo‐controlled study the effects of clovoxamine on sleep were evaluated. Each of 12 healthy male volunteers was given clovoxamine (50 and 150 mg) and placebo according to a repeated‐measures randomized Latin square design. All night sleep EEGs and subjective evaluations of sleep were recorded on each night. Clovoxamine was found to have effects on sleep EEG and subjective evaluation that were consistent with findings reported for other antidepressants such as imipramine.