The effects of circuit resistance training on plasma progranulin level, insulin resistance and body composition in obese men.

Alireza Safarzade,Hamid Alizadeh,Zainab Bastani

doi:10.1515/hmbci-2019-0050

Abstract

Background Progranulin (PGRN) is implicated in obesity and insulin resistance (IR). The aim of this study was to evaluate the effects of 8 weeks of circuit resistance training (CRT) on plasma PGRN, IR and body composition in obese men. Materials and methods Twenty-eight healthy obese men [age: 36 ± 7.7 years, body weight (BW): 96.4 ± 15.6 kg, body mass index (BMI): 32.4 ± 4.5 kg/m2] completed the study. Subjects were randomly assigned to two groups of control and training. Subjects in the training group underwent training for 8 weeks, 3 times a week. Blood samples and anthropometric characteristics were taken before the commencement of the exercise protocol and 72 h after the last training session. The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure IR. Results BW, BF%, BMI, waist-hip ratio (WHR), HOMA-IR and plasma PGRN levels except lean body mass (LBM) were significantly reduced in the training group (p < 0.05). Additionally, except for LBM, subjects in the training group had significantly decreased BW, BF%, BMI, WHR, HOMA-IR and plasma PGRN levels compared to changes in those in the control group (p < 0.05). Significant correlations were found between the changes in plasma PGRN and the changes in insulin, HOMA-IR and BMI (p < 0.05). Conclusions The findings showed that 8 weeks of CRT improved body composition and IR which were accompanied by reduced plasma PGRN levels. This study suggests that CRT has the potential for obese individuals to counteract obesity-associated health impairments.

Highlights

Obesity creates a chronic systemic low-grade inflammation, which is considered as one of the pathogenic factors for insulin resistance (IR) [1]
Except for lean body mass (LBM) (p = 0.17, ∆ + 0.5%), body weight (BW) (p = 0.025, ∆ − 2.25%), BF% (p = 0.011, ∆ − 4.45%), body mass index (BMI) (p = 0.018, ∆ − 2.25%) and waist-hip ratio (WHR) (p = 0.014, ∆ − 3.16%) were significantly reduced in the training group
Our result showed that 8 weeks of chronic circuit resistance exercise training (3 times per week, 50–85% 1-RM) significantly decreased plasma PGRN levels in obese men

Summary

Introduction

Obesity creates a chronic systemic low-grade inflammation, which is considered as one of the pathogenic factors for insulin resistance (IR) [1]. Available evidence shows the potential of chronic resistance training for alleviating obesity-induced systemic low-grade inflammation by reducing two major. The aim of this study was to evaluate the effects of 8 weeks of circuit resistance training (CRT) on plasma PGRN, IR and body composition in obese men. Results: BW, BF%, BMI, waist-hip ratio (WHR), HOMA-IR and plasma PGRN levels except lean body mass (LBM) were significantly reduced in the training group (p < 0.05). Except for LBM, subjects in the training group had significantly decreased BW, BF%, BMI, WHR, HOMA-IR and plasma PGRN levels compared to changes in those in the control group (p < 0.05). Conclusions: The findings showed that 8 weeks of CRT improved body composition and IR which were accompanied by reduced plasma PGRN levels. This study suggests that CRT has the potential for obese individuals to counteract obesity-associated health impairments

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Conclusion