Abstract
Chunghyul-dan (CHD) is a herbal complex containing 80% ethanol extract and is composed of Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, Gardeniae Fructus, and Rhei Rhizoma. We have published several experimental and clinical research articles on CHD. It has shown antilipidemic, antihypertensive, antiatherosclerotic, and inhibitory effects on ischemic stroke recurrence with clinical safety in the previous studies. The antilipidemic effect of CHD results from 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase and pancreatic lipase-inhibitory activity. The antihypertensive effect likely results from the inhibitory effect on endogenous catecholamine(s) release and harmonization of all components showing the antihypertensive effects. Furthermore, anti-inflammatory and antioxidant effects on endothelial cells are implicated to dictate the antiatherosclerotic effects of CHD. It also showed neuroprotective effects on cerebrovascular and parkinsonian models. These effects of CHD could be helpful for the prevention of the recurrence of ischemic stroke. Therefore, we suggest that CHD could be a promising medication for treating and preventing cerebrovascular and cardiovascular diseases. However, to validate and better understand these findings, well-designed clinical studies are required.
Highlights
Background, History, and DevelopmentChunghyul-dan (CHD) is a capsulated herbal complex, which contains an 80% ethanol extract (300 mg per capsule) composed of Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, Gardeniae Fructus, and Rhei Rhizoma (Table 1)
HRHT, which consists of Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, and Gardeniae Fructus, is one of the most famous herbal medicines for treating cardiovascular and cerebrovascular diseases
248.6 ± 29.2 mg/dL (p < 0.05) There was no significant difference between CHD 1 and 2 group Atorvastatin was superior to 600 mg or 1200 mg CHD
Summary
Chunghyul-dan (CHD) is a capsulated herbal complex, which contains an 80% ethanol extract (300 mg per capsule) composed of Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, Gardeniae Fructus, and Rhei Rhizoma (Table 1). It is known as Daehwang-Hwang-Ryung-Haedok-Tang (Daio-orengedokuto in Japanese), which means HwangRyung-Haedok-Tang (HRHT, Orengedokuto in Japanese) plus Daehwang (Rhei Rhizoma). HRHT, which consists of Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, and Gardeniae Fructus, is one of the most famous herbal medicines for treating cardiovascular and cerebrovascular diseases. Since 2002, we have reported extensive experimental and clinical research articles related to CHD It has shown antilipidemic, antihypertensive, antiatherosclerotic, and enhancing effects on vascular endothelial cells. This review introduces and provides the effects of CHD on cardiovascular and cerebrovascular diseases
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