Abstract
Introduction Sildenafil inhibits phosphodiesterases type 5, an enzyme that metabolizes cGMP. It is approved for the treatment of erectile dysfunction and pulmonary arterial hypertension. Early clinical studies showed a beneficial effect in endothelial dysfunction and severe systolic heart failure. The aim of this study was to examine the efficacy and tolerability of chronic sildenafil on exercise capacity and quality of life in patients with stable systolic heart failure.
Highlights
Sildenafil inhibits phosphodiesterases type 5, an enzyme that metabolizes cGMP
The International index of erectile function (IIEF), Beck's depression inventory (BDI) and the Minnesota living with heart failure questionnaire (LHFQ) were used to assess the functional outcome
The baseline IIEF score showed evidence of erectile dysfunction in both groups (EF domain, S = 12.6 ± 2.8 P = 10.1 ± 3.5), with significant improvement in only the overall satisfaction domain in the S group at W16 compared to placebo (+2.5 points; P = 0.04)
Summary
Sildenafil inhibits phosphodiesterases type 5, an enzyme that metabolizes cGMP. It is approved for the treatment of erectile dysfunction and pulmonary arterial hypertension. Clinical studies showed a beneficial effect in endothelial dysfunction and severe systolic heart failure. The aim of this study was to examine the efficacy and tolerability of chronic sildenafil on exercise capacity and quality of life in patients with stable systolic heart failure. It was not statistically significant between groups (Fig. 1). Two of 12 patients on S and non in P were withdrawn from the study
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