Abstract
Chromium (VI) is a genotoxic metal which is rapidly reduced to chromium III by cellular enzymes. During the reduction to the less‐toxic trivalent form, chromium can react with macromolecules including DNA and cause lesions.In this investigation, the evaluation of the genotoxic effects of chromium (VI) on the peripheral blood erythrocytes of Hybro chicken has been carried out. The effect of vitamin C on the genotoxicity caused by chromium (VI) has also been investigated. Chickens were divided into 5 groups (I–V) of 7 individuals each and orally administered varying concentrations of Cr (VI) and vitamin C for four months. Our results show that four months ingestion of two different concentrations of chromium (VI) as well as chromium (VI) + vitamin C resulted in a significant increase in micronucleated erythrocytes. No protective effect of vitamin C in the concentrations applied was observed. Based on our data we confirm that Hybro chicken could be used as an alternative test for the evaluation of the genotoxic effects of environmental contaminants.
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