The effects of chloralose on the brainstem auditory evoked potential of the rat

Abstract

The effects of alpha-chloralose were examined on the brainstem auditory evoked potential of the rat. Subjects were given one of four different doses of chloralose. These were a sedative dose (50 mg/kg), an anaesthetic dose (100 mg/kg), a usually fatal dose (150 mg/kg) or an invariably fatal dose (200 mg/kg). Recordings were made 60 min later. There was no evidence of any dose-dependent increase or decrease in the amplitudes of the four principal components (waves I, II, III and IV) of the brainstem auditory potential. There were only minor dose-dependent increases in latency. These were less than 0.1 msec for waves I, II and III and just over 0.1 msec for wave IV. Wave IV was the component which was most sensitive to chloralose, although this was apparent only at a large dose. In general, the latencies showed little or no difference from those recorded previously from awake animals. The results are discussed in relation to a series of experiments, where animals were initially immobilized with chloralose in order to study the effects of a variety of pharmacological agents on the brainstem auditory potential.