Abstract
SummaryThe effects of the hypocholesterolemic agents, trans-1,4-bis- (2-chloro-benzylaminomethyl) -cyclohexane dihy dro-chloride (AY9944) and beta-benzalbutyric acid (BBB), on the level (activity) of delta-aminolevulinic acid synthetase (ALAS) in the mitochondria of livers of mice injected with certain porphyrinogenic compounds were studied. The porphyrinogenic agents employed were allylisopropylacetamide (AIA) and 3,5-dicarbethoxy-1,4-dihydro-2,4,6-trimethylpyridine (DDC). All substances were administered parenterally.Both AY-9944 and BBB injections prevented the increase in hepatic mitochondrial ALA-synthetase levels which otherwise follow the injection of AIA or DDC. AY-9944 administration also produced a consistent decrease in serum cholesterol levels. These data suggest that a decrease in the hepatic steroid “pool” and presumably that of 5-beta-H-steroid metabolites, as reflected by the serum cholesterol level, is associated with the observed decrease in hepatic mitochondrial ALAS.The present data th...
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