Abstract
AbstractAn organ culture assay system using cockroach leg regenerates and fat body has been developed in which compounds that either inhibit molting hormone metabolism or act as molting hormone antagonists can be tested. Representatives of three classes of compounds were tested in the system: ecdysteroids, azasteroids, and nonsteroidal amines and amides. Inhibitory compounds were found in all three of the classes. Certain of these inhibitors represent a new class of insect hormonal compounds with a novel mode of action—the disruption of molting hormone metabolism.
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