Abstract
The calcium complex formation equilibria of heparin were investigated by potentiometry, using a new calcium ion selective electrode. The measurements were performed in aqueous solutions adjusted to 0.3 constant ionic strength by lithium, sodium, potassium and magnesium chlorides, respectively. The data reflect the effect of the latter cations on the calcium ion coordination of heparin resulting not only in the change of the equilibrium constants, but also in that of the composition of the dominating species in the solution.
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