Abstract
Canine cerebellar explant cultures were employed as a model for studying the effects of the virus associated with demyelinating canine distemper encephalomyelitis. Cultures which were inoculated after four to seven days of growth with distemper virus (Lederle strain) had beginning cytopathic effect (CPE) in the peripheral outgrowth on the eighth post-inoculation day. The cells predominantly affected were astroglia and mesenchymal cells. The cellular lesions consisted of inclusion body development (intracytoplasmic and intranuclear), syncytial giant cell formation, and production of a reticular pattern in the outgrowth. Astrocytes subsequently became affected in the inner outgrowth and explant. Cellular degeneration was common, but a high degree of apparent coexistence of virus (inclusion bodies) and cells was a characteristic feature.
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