Abstract
Rats treated with 10, 20, 40, or 80 mg/kg/day of calcium carbimide showed a dose-related depression of body weight gain, food consumption, and feed efficiency that was greatest at the 80 mg/kg/day dose level. Histometric quatiification of the thyroid glands of these animals showed a marked hyperplasia of follicular epithelium, loss of colloid, and capillary hyperemia compared with control animals. Administration of 80 mg/kg/day of thyroid powder together with 80 mg/kg/day of calcium carbimide resulted in a marked increase in total food consumption with a concurrent decrease in feed efficiency and produced a colloid “storage phase” in the thyroid gland. The physiologic change characterized by a reversal of the morphologic pattern of the thyroid gland from severe hyperplasia to colloid storage may be interpreted as indicative of a significant decrease in the activity of the thyroid gland.
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