Abstract
BackgroundExplore the interaction between apolipoprotein E (Apo E), phospholipase A2 (PLA2) and β2 adrenergic receptor (β2-AR) gene polymorphisms and lipid profiles in an elderly Chinese population.MethodsFive hundred subjects aged 65 to 74 years were randomly selected from a community in southern Taiwan to assess the relationship between Apo E, PLA2 and β2-AR gene polymorphisms and lipid profiles. Two hundred sixty-seven participants agreed to have venous blood drawn for DNA studies.ResultsTwo statistically significant differences were noted in TC and LDL-C in the Gln27Glu of the β2-AR gene polymorphism (P = 0.007, P = 0.022). The low-income group had a higher HDL-C level (p = 0.076). The Gln27Glu polymorphism Glu/Glu or Gln/Glu subjects had lower TC levels compared to the Gln27Glu polymorphism Gln/Gln subjects (p = 0.092). Lower TC levels (p = 0.082) and lower LDL-C levels (p = 0.045) in subjects with the Cys19Arg16Glu27 haplotype. Lower TC levels (p = 0.06) were also noted in subjects with the Cys19Gly 16Glu27 haplotype. On the other hand, higher VLDL-C levels (p = 0.185) and higher triglyceride (TG) levels (p = 0.190) were noted in subjects with the Cys19Gly 16Gln27 haplotype. The ε2 allele combined with low income had a positive effect on HDL-C (p = 0.0011), after adding the income factor in this study.ConclusionWhen the effects of Apo E and PLA2 on lipid profiles were included in this study, β2-AR gene polymorphisms reduced significant effect on lipid profiles. Similarly, low income increased effect on HDL-C. This study appeared that the results of gene-gene and gene-environment interaction, it should be considered in further studies for lipid profiles.
Highlights
Explore the interaction between apolipoprotein E (Apo E), phospholipase A2 (PLA2) and β2 adrenergic receptor (β2-Adrenergic receptors (ARs)) gene polymorphisms and lipid profiles in an elderly Chinese population
We explored the interactive effects among PLA2 and the Apo E polymorphism, sex and income on high-density lipoprotein cholesterol (HDL-C), using multivariate regression analysis with the Jump 5.1 for Windows software package
We found that the ε2 allele combined with low income had a positive effect on HDL-C (p = 0.0011)
Summary
Explore the interaction between apolipoprotein E (Apo E), phospholipase A2 (PLA2) and β2 adrenergic receptor (β2-AR) gene polymorphisms and lipid profiles in an elderly Chinese population. Endogenous catecholamines were involved in the regulation of adipose tissue lipolysis, nonesterified fatty acid distribution, lipoprotein metabolism, obesity, glucose homeostasis, diabetes mellitus, blood pressure and metabolic syndrome [1]. Adrenergic receptors (ARs) can regulate lipid mobilization, energy expenditure (page number not for citation purposes). Lipids in Health and Disease 2008, 7:20 http://www.lipidworld.com/content/7/1/20 and glycogen breakdown through these endogenous catecholamines [1]. Many studies have demonstrated associations between β2 adrenergic receptor (β2-AR) gene polymorphisms and various diseases: obesity, type 2 diabetes (T2DM) [2], metabolic syndrome, metabolic disorders [3,4] and hypertension [5,6]. The β2-AR gene may constitute a potential candidate gene to explain part of the genetic predisposition to human obesity and related traits
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