The effects of basic characteristics of patients on non-motor symptoms and the relationship between motor symptoms and non-motor symptoms in patients with Parkinson's disease

Abstract

Objective To investigate whether sex, age-of-onset, education and asymmetry affect non-motor symptoms(NMS)in Parkinson disease, and to analyze the relationship between motor symptoms and NMS in Parkinson’s disease. Methods The detailed clinical information of 157 patients with idiopathic Parkinson's disease(PD)was recorded and followed up.The data was calculated with SPSS statistic software.Sex had an impact on sleeping disorder(P 0.05). The higher the scores of postural instability and gait difficulty(PIGD)were, the lower the Mini-Mental State Examination(MMSE)score was(β=-1.837, P=0.004). The higher the tremor score was, the higher the Hamilton Depression Scale(HAMD)score was(β=3.460, P=0.001). The higher the rigidity akinesia score was, the higher the autonomic dysfunction score was(β=0.104, P=0.006). Conclusions The non-motor symptoms of Parkinson's disease are affected by the age, sex and cultural level.Symmetry-or-not does not affect Parkinson's disease.Non-motor symptoms and motor symptoms are closely linked.The encountered posture and gait abnormalities of patients should trigger physician alerts to focus on patients’ cognitive function.The encountered tremor of patients should trigger physician alerts to focus on their emotional changes.Facing to the patient with rigidity and less moving, physician should alert to the occurrence of autonomic symptoms. Key words: Parkinson disease; Movement disorders; Non-motor symptom; Risk factors