Abstract
The effects of aspirin and dipyridamole on the metabolism of exogenous 14C-arachidonic acid were investigated in intact human platelets in vitro. The formation of thromboxane B (TXB ) and 12-hydroxy-5, 8,10-heptadecatrienoic acid (HHT) was inhibited dose dependently by aspirin but not by dipyridamole. Neither was the aspirin caused inhibition in TXB 2 and HHT formation modified by dipyridamole. At high concentrations caused a slight increase in the amount of 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) and a corresponding decrease in that of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE).This was seen also when aspirin was combined with dipyridamole. At high concentrations (100 μM and 1 mM) dipyridamole caused an increased formation of 12-HETE and an unidentified metabolite group. The present study indicates that dipyridamole has no effect on the formation of the cyclo-oxygenase metabolites in human platelets but the lipoxygenase pathway seems to be stimulated by dipyridamole.
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