Abstract
Radioactive microspheres were used to determine the effects of hypercapnia and hypocapnia on regional myocardial and renal blood flow and cardiovascular hemodynamics in an animal model in which arterial pH and pO 2 were maintained at constant levels. An increase in arterial pCO 2 effected an increase in both transmural coronary and intrarenal blood flow which was due to a reduction in coronary and renal vascular resistance. A marked reduction in arterial pCO 2, however, did not influence coronary and renal flow or resistance. When compared to the hypocapnic state, hypercapnia and the resultant increase in coronary blood flow provided a modest improvement in ventricular work at the same level of myocardial contractility.
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