The Effects of Artemisia Plant and Its Components Against Respiratory Viruses Like Influenza and Their Mechanisms of Action

Abstract

Context: Artemisia genus and its chemical constituents show antiviral activity against different viruses. The aim of this study was to review the effects of selected Artemisia species and their components against respiratory viruses like influenza and coronavirus. Methods: All the articles published in English or Persian related to the effects of Artemisia and its components on viral respiratory infections and relevant mechanisms of action were searched throughout Medline, Science Direct, Scopus, Ebsco, Google Scholar, and Cochrane Library Database from 1966 up to April 2020. Results: A few numbers of Artemisia species such as A. scoparia, A. rupestris, and A. annua and their components showed efficacy against the influenza virus and coronaviruses. Furthermore, some chemical compounds isolated from Artemisia species, like rupestonic acid, showed potent anti-influenza activity. The mechanism of antiviral activity was also determined for some of these compounds. Conclusions: The present study summarized the efficacy of a number of Artemisia species and their components against respiratory viruses like influenza and coronavirus. Future studies on other Artemisia species may lead to the discovery of new antiviral drugs against the influenza virus and coronaviruses.