Abstract
Oral cancer is the 5th leading cause of male cancer mortality in Taiwan, and chewing areca quid (AQ) has been linked to the development of this malignancy. AQ is composed of areca nut, slaked lime, and Piper betle inflorescence or leaf. Areca nut extract (ANE) contains polyphenolics and alkaloids. The polyphenols in ANE have been implicated to exert oxidative damages and may link to oral carcinogenesis. In this study, the cell viability effects of ANE in oral cancer cells were determined by MTT (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. The results demonstrated that the ANE had cytotoxic effects on oral cancer cells. In cell morphology, ANE treatment resulted in intracellular vacuole formation, cytoplasmic blebbing, spike, blister, and increas of apoptosis body. Results from this study indicate that low-dose (25μg/ml) ANE-induced oxidative stress in oral cancer cells may promote cell survival.
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