The effects of aqueous extract of Lavandula angustifolia flowers in glutamate-induced neurotoxicity of cerebellar granular cell culture of rat pups

Abstract

In the present study, neuroprotective effect of Lavandula angustifolia flower aqueous extract in glutamate-induced neurotoxicity in rat pups cerebellar granular cell culture was investigated. The extract at doses of 10 μg ml −1, 100 μg ml −1, 1 mg ml −1 and 10 mg ml −1 was applied to culture flasks. The extract at doses of 100 μg ml −1 and 1 mg ml −1 significantly blocked glutamate-induced neurotoxicity, with the most effective dose being 1 mg ml −1. On the other hand, 10 mg ml −1 dose of extract increased the dead cell with respect to glutamate group, despite being found insignificant statistically. As a result, L. angustifolia protected the neurons against glutamate toxicity.