Abstract
In clinical, various kinds of anti-bone-resorptive drugs have been used for the treatment of bone disorders such as osteoporosis. However, it remains elusive how they affect the osteoclast dynamics in living bone tissues. We recently succeeded in visualizing cellular dynamics of bone-resorbing osteoclasts and their precursors with intravital bone imaging techniques. We found that active vitamin D analogs could regulate the migratory behavior of circulating osteoclast precursors, whereas bisphosphonates could affect mature osteoclasts and inhibit bone resorption within a short period. Here we show the latest data of in vivo effects of anti-bone resorptive drugs currently developed in the world.
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