The effects of antalarmin on behavioural and biochemical aspects of chronic nicotine administration and acute nicotine withdrawal in rats

Abstract

Event Abstract Back to Event The effects of antalarmin on behavioural and biochemical aspects of chronic nicotine administration and acute nicotine withdrawal in rats M. Palotai1, Z. Bagosi1*, K. Csabafi1 and G. Szabó1 1 University of Szeged, Department of Pathophysiology, Hungary Introduction: In the present experiments we studied the actions of selective CRF1 receptor antagonist antalarmin on the hyperactivity elicited by chronic nicotine treatment and the hypoactivity induced by consecutive nicotine withdrawal in rats. Methods: 2 mg/kg nicotine was injected intraperitoneally for 7 days, 4 times/day and 0,1 mg/2 ml antalarmin was administered intracerebroventricularly on the 8th and the 9th day’s morning. An in vivo conducta system based upon open field test was used to study horizontal activity, vertical activity and total drive of the animals. An in vitro superfusion system was used to determine striatal dopamine and amygdalar GABA release from brain slices; meanwhile plasma corticosterone was extracted and detected by a chemofluorescent assay from trunk blood. Results: Antalarmin inhibited considerably the anxiogenic behaviour and the elevated plasma corticosterone level, striatal dopamine and amygdalar GABA releases observed at 12 hours after the last nicotine administration. It also antagonized remarkably the anxiolytic behaviour and the reduced corticosterone level observed at 24 hours after the last nicotine administration. However the changes of dopamine release from the striatum and the GABA release from the amygdala were insignificant at this time. Conclusion: Antalarmin ameliorates most of the behavioural and biochemical consequences of chronic nicotine administration and consecutive nicotine withdrawal. Acknowledgements This work was supported by the following grants: ETT 355-08/2009 and TÁMOP 4.2.1B. Keywords: Behaviour and cognition, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Behaviour and cognition Citation: Palotai M, Bagosi Z, Csabafi K and Szabó G (2011). The effects of antalarmin on behavioural and biochemical aspects of chronic nicotine administration and acute nicotine withdrawal in rats. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00014 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. Z. Bagosi, University of Szeged, Department of Pathophysiology, Szeged, Hungary, bagosi@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers M. Palotai Z. Bagosi K. Csabafi G. Szabó Google M. Palotai Z. Bagosi K. Csabafi G. Szabó Google Scholar M. Palotai Z. Bagosi K. Csabafi G. Szabó PubMed M. Palotai Z. Bagosi K. Csabafi G. Szabó Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.