Abstract
To investigate whether topically administered hemostatic agents ankaferd blood stopper and microporous polysaccharide hemospheres can decrease epidural fibrosis after laminectomy in rats. Eighteen adult male Sprague-Dawley rats were equally and randomly divided into three groups. In the treatment groups, ankaferd blood stopper and microporous polysaccharide hemospheres topically administrated upon duramater surface after laminectomy. Fibroblast count, epidural fibrosis and arachnoidal involvement were evaluated and graded histopathologically. Our data revealed that the count of fibroblasts, the grading of epidural fibrosis and arachnoideal involvement in the rats treated with microporous polysaccharide hemospheres were significantly less than the control group. Although the arachnoideal involvement in ankaferd blood stopper group were significantly less than the control group, there were no statistical differences when comparing the grading of epidural fibrosis and the fibroblasts count between the treatment groups and the control group. The ankaferd blood stopper and microporous polysaccharide hemospheres reduced epidural fibrosis and arachnoideal involvement after laminectomy in rats.
Highlights
Surgical procedure and sample preparationSurgery for lumbar disc herniations are performed over than one million patients all over the world in every year[1,2]
Our data revealed that the count of fibroblasts, the grading of epidural fibrosis and arachnoideal involvement in the rats treated with microporous polysaccharide hemospheres were significantly less than the control group
The arachnoideal involvement in ankaferd blood stopper group were significantly less than the control group, there were no statistical differences when comparing the grading of epidural fibrosis and the fibroblasts count between the treatment groups and the control group
Summary
Surgical procedure and sample preparationSurgery for lumbar disc herniations are performed over than one million patients all over the world in every year[1,2]. The causes of failed back syndrome are diskectomy for wrong level, recurrent or persistent disc herniation, iatrogenic instability, central or lateral stenosis, arachnoiditis, and spinal epidural fibrosis[3,4,5]. Impaired axoplasmic transport and excretion of inflammatory mediators following the decreasing of arterial supply lead to intractable radicular pain[1,3,5,7]. Both back and radicular pain associated with the EF are resistant to physical, medical and surgical treatments[1,2,3,4,5,6,7,8]. Epidural fibrosis is associated with an increased complication rate in revision spine surgery[9,10]
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