Abstract
This inquiry into the effects of cerebral anemia has been undertaken for three reasons: ( 1 ) to produce experimentally the lesions in the cerebral cortex that many observers have described as characteristic of cerebral anemia in man; ( 2 ) to obtain additional evidence as to the endurance of anemia by cerebral nerve cells, and ( 3 ) to attempt to correlate these lesions with the symptoms that may occur as the result of anemia. Spielmeyer, 1 in recent years, has investigated the pathologic changes in the brains of patients dying from various forms of vascular disease which are supposed to produce cerebral anemia. He has described lesions, consisting of many shrunken, homogeneous, dark-staining cells that he considers characteristic of cerebral ischemia. We have attempted to reproduce this picture in animals by shutting off the blood supply to the brain for various periods of time. Cannon and Burket (1913) 2 briefly summarized the literature relating
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