Abstract
1. 1. When guinea-pig brain and kidney cortex slices were incubated in the presence of the carbonic anhydrase inhibitor, p-toluenesulphonamide, the steady-state tissue concentration of sodium was increased and that of potassium was decreased. 2. 2. Although no residual carbonic anhydrase activity could be detected in the presence of the inhibitor and the oxygen uptake was reduced, the steady-state turnover rates (or rate constants) of sodium and potassium remained constant. However, the exchange rates (μmoles/g/min) were increased for sodium and decreased for potassium. 3. 3. These results are in accordance with, but do not prove, the assumption that carbonic anhydrase plays a role in ion transport in brain and kidney cortex.
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