Abstract
The action of amiodarone (1.5 × 10 −5 M) on sinus node activity of spontaneously beating isolated right atria of rabbit at 30°C was investigated using a microelectrode techniques. The drug significantly increased the action potential duration and decreased the slope of diastolic depolarization, both effects leading to a reduction of the sinus rate. In contrast to β-blocking agents, amiodarone reduced but did not completely abolish the adrenergic effects on the sinus node activity. It is concluded that the amiodarone-induced bradycardia observed in clinical trials might be due to a direct effect of the drug on the sinus node.
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