Abstract
Introduction Several studiesdemonstrated that the use of alternate-day corticosteroid therapy maintains control of autoimmune diseases due to the prolongation of their therapeutic effect beyond their metabolic effect, with a significant decrease in side effects in patients. For this reason, the current recommendation for the use of these medications is in a short cycle to avoid adverse effects when used frequently and for prolonged periods of time. Objectives To learn variations in serum levels of autoantibodies in autoimmune diseases treated with steroids on alternate days, as well as whether there are differences in the response to them depending on the type of disease. Study Design. A descriptive, retrospective, and cross-sectional study was conducted in which serum autoantibody levels were compared at the time of diagnosis and three months after alternate-day corticosteroid therapy. Results We included 106 patients from three autoimmune connective tissue diseases (systemic lupus erythematosus, Sjögren syndrome, and Hashimoto's thyroiditis) and observed a statistically significant decrease in serum autoantibody levels both in patients with lupus and those with Hashimoto's thyroiditis, regardless of the sex of the patients, as well as the type of steroids used. Conclusions Treatment with alternate-day corticosteroids achieved a statistically significant decrease in serum autoantibody levels in patients with systemic lupus erythematosus and Hashimoto's thyroiditis.
Highlights
Several studiesdemonstrated that the use of alternate-day corticosteroid therapy maintains control of autoimmune diseases due to the prolongation of their therapeutic effect beyond their metabolic effect, with a significant decrease in side effects in patients
When a secondary activation of lymphocytes is associated with the production of antibodies against various antigens of the body, it is called humoral autoimmune disease and, in this case, the treatment involves providing drugs that stop the uncontrolled production of autoantibodies to prevent the perpetuation of organ damage. e medications used for this purpose could trigger side effects that deteriorate the quality of life of patients and are usually dose dependent
We presented the response observed in serum levels of autoantibodies in patients with autoimmune diseases treated with alternateday corticosteroid therapy between January 2008 and January 2013 at the Clinical Immunology and Allergy Service of the National Medical Center 20 de Noviembre, ISSSTE, Mexico
Summary
Several studiesdemonstrated that the use of alternate-day corticosteroid therapy maintains control of autoimmune diseases due to the prolongation of their therapeutic effect beyond their metabolic effect, with a significant decrease in side effects in patients. For this reason, the current recommendation for the use of these medications is in a short cycle to avoid adverse effects when used frequently and for prolonged periods of time. Several publications have been demonstrated that the use of alternate-day corticosteroid therapy maintains control of autoimmune diseases due to the prolongation of their therapeutic effect beyond their metabolic effect, with a significant decrease in side effects [12,13,14]. We presented the response observed in serum levels of autoantibodies in patients with autoimmune diseases treated with alternateday corticosteroid therapy between January 2008 and January 2013 at the Clinical Immunology and Allergy Service of the National Medical Center 20 de Noviembre, ISSSTE, Mexico
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