Abstract
The effects of oral treatment with methyldopa 1 to 2.75 Gm. per day for 7 to 13 days on arterial pressure, urine volume, glomerular filtration rate, renal plasma flow, and renal vascular resistance were studied in both the supine and tilted positions in 8 hospitalized patients with sustained essential hypertension and impaired renal function. Despite a decrease in arterial pressure during treatment with methyldopa, GFR did not decrease while renal plasma flow increased in the supine and tilted positions from 302 to 350 ml. per minute and from 233 to 306 ml. minute, respectively. A significant increase in urine volume was also observed in both positions. These effects of drug administration were accompanied by a decrease in renal vascular resistance. The results of this study provide a rational basis for the use of methyldopa in the treatment of ambulatory hypertensive patients with impaired renal function.
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