Abstract
The Effects of Allyl Chloride on Ca2+, Caz+‐Free CaM, cAMP and Ca24/CaM‐PK II Activity in Nerve Cells: Keqin Xie, et at. Institute of Toxicology, Shandong Medical University—Nerve cells in a culture from chicken embryo brain were used to study the allyl chloride‐induced effects on the contents of intracellular Ca2+, Ca2+‐free CaM, cAMP and the activity of Ca2+/CaM‐PK II. The results showed that with the increase in the concentration of allyl chloride there was a significant increase in the content of Ca2+and cAMP, and the activity of Ca2~/CaM‐PK II in the cells (P<0.01), but a marked decrease in Ca2 + ‐free CaM (P< 0.01). The results suggest that the neurotoxicity of allyl chloride might be related to the increase in intracellular Ca2+ and the activation of CaM and Ca2+/CaM‐PK II, eventually leading to the accumulation of degenerative MT in the nerve axon.
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