Abstract
In order to determine whether the function of alveolar macrophages (AM) is modulated by aging, we measured the TNF-α production, phagocytic function, and surface antigen expression of AM from young and old mice. When AM were primed by IFN-γ (500 units/ml) and triggered by LPS (100 μg/ml), TNF-α production by AM was significantly smaller in old mice as cmpared with young mice (young mice: 161.7 ± 28.2 units/ml; old mice: 89.3 ± 13.6 units/mlf, P < 0.05). The percentage of AM which phagocytosed latex particles (more than one particle) in old mice was significantly lower than in young mice (young: 78.1 ± 2.5%; old: 62.8 ± 3.4%, P < 0.05). Ia antigen expression of the AM was significantly higher and asialo-GM1 antigen expression was significantly lower in old mice than in young mice (Ia: young, 0.030 ± 0.005; old, 0.092 ± 0.024, P < 0.05; asialo-GM1: young, 0.97 ± 0.01; old, 0.75 ± 0.07, ( P < 0.01). These results suggest that alveolar macrophage function is at least decreased in part with aging in mice.
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