The effects of aging on the brain activation pattern during a speech perception task: an fMRI study.

Abstract

In the present study, brain activation associated with speech perception processing was examined across four groups of adult participants with age ranges between 20 and 65years, using functional MRI (fMRI). Cognitive performance demonstrates that performance accuracy declines with age. fMRI results reveal that all four groups of participants activated the same brain areas. The same brain activation pattern was found in all activated areas (except for the right superior temporal gyrus and right middle temporal gyrus); brain activity was increased from group 1 (20-29years) to group 2 (30-39years). However, it decreased in group 3 (40-49years) with further decreases in group 4 participants (50-65years). Result also reveals that three brain areas (superior temporal gyrus, Heschl's gyrus and cerebellum) showed changes in brain laterality in the older participants, akin to a shift from left-lateralized to right-lateralized activity. The onset of this change was different across brain areas. Based on these findings we suggest that, whereas all four groups of participants used the same areas in processing, the engagement and recruitment of those areas differ with age as the brain grows older. Findings are discussed in the context of corroborating evidence of neural changes with age.