Abstract
ObjectivesThis study aims to explore the age-related changes in cerebral cortex activation and functional connectivity (FC) during finger-to-thumb opposition movement based on video games (FTOMBVG). MethodsA electronic fingercot was developed for FTOMBVG. The oxygenated hemoglobin concentration (Delta [HbO]) signals, measured by functional near-infrared spectroscopy (fNIRS), were recorded from prefrontal cortex (PFC), motor cortex (MC) and occipital lobe (OL) of two groups of subjects (old and young). ResultsThe cognitive region of the old group showed bilateral activation, while the young group only showed unilateral activation. Both groups showed a wide range of bilateral activation in the motor region. The FC between cognitive region and motor region of the old group was enhanced considerably. ConclusionChanges in cerebral cortex activation and the FC of different brain regions in the old group help explain the decline in cognitive executive and motor control function in the old from the perspective of brain functional structure, and provide a theoretical reference for the prevention of neural diseases caused by aging.
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