Abstract
Background: Oxidative stress (OS) plays an important role in the progression of many aging-related diseases. Exercises can delay this kind of progress, but aerobic exercise is the most commonly used type of training among older adults; therefore, its influence needs to be further verified. Methods: A literature search was conducted in eight electronic databases, including Cochrane, EMBASE, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Date, and SinoMed from their inception to April 2020. Methodological quality was assessed using Cochrane RoB tool v2.0 for individual studies, and RevMan 5.3 software was used to perform the meta-analysis. Results: The meta-analysis included 20 studies, involving 1,170 older adults. The results showed that regular aerobic exercise could reduce blood oxidant markers, including malondialdehyde (MDA; SMD=−1.80, 95% CI −2.46 to −1.14, p<0.001) and lipid peroxide (LPO; SMD=−1.12, 95% CI −2.03 to −0.22, p=0.02), and increase the levels of antioxidant factors, such as nitric oxide (NO; SMD=0.89, 95% CI 0.37–1.41, p<0.001), superoxide dismutase (SOD; SMD=0.63, 95% CI 0.25–1.01, p=0.001), and total antioxidant capacity (TAC; SMD=1.22, 95% CI 0.45–1.98, p=0.002), with clear statistical significance. It may also improve the levels of other OS markers, such as 8-OHdG, 8-isoPGF2, VE, and reduced glutathione/oxidized glutathione (GSH/GSSG). Conclusion: Regular aerobic exercise may have a positive effect on the OS levels of older adults by reducing some oxidant markers and increasing antioxidant marker levels.
Highlights
IntroductionIt is characterized by the gradual accumulation of damage to cells, progressive functional decline, and increased susceptibility to disease (Finkel and Holbrook, 2000)
Aging is a dynamic, degenerative, biological, and time-dependent process
The findings in the present review show that regular aerobic exercise greatly improves the efficiency of enzymatic and nonenzymatic antioxidant defense systems and strengthens the body’s ability to remove pro-oxidants
Summary
It is characterized by the gradual accumulation of damage to cells, progressive functional decline, and increased susceptibility to disease (Finkel and Holbrook, 2000). Oxidative stress (OS) takes part in the development of aging, which has been proved to be associated with aging as well as agerelated diseases (Dröge, 2002; Campisi et al, 2019; Warraich et al, 2020). Oxidative stress (OS) plays an important role in the progression of many aging-related diseases. Exercises can delay this kind of progress, but aerobic exercise is the most commonly used type of training among older adults; its influence needs to be further verified
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