Abstract
Adrenal regulation of the vasopressincontaining fibers to the portal capillary system in the zona externa of the median eminence was studied in the rat. Tissue sections of the hypothalamus were examined by immunoperoxidase technique and light microscopy using antisera to oxytocin and arginine vasopressin, and an antiserum which reacts with all rat neurophysins. These peptides were localized in the intact normal rat and after adrenalectomy, glucocorticoid replacement with dexamethasone, and after dehydration. The effect of adrenalectomy was also examined in the homozygous Brattleboro rat with diabetes insipidus (DI rat) which lacks arginine vasopressin and, arginine vasopressinneurophysin. In the zona externa of the normal rat a small number of arginine vasopressin and neurophysin- containing fibers, and an occasional one containing oxytocin were traced to the portal capillary bed. The zona externa of the unoperated DI rat contained only an occasional neurophysin- and oxytocin-reactive fiber. In the normal...
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