The Effects of Administration of Total Glucoside Peony (TGP) on Autoimmune Diseases: Clinical and Laboratory Observations as Preliminary Research

Abstract

Autoimmune diseases cause the host immune system to produce antibodies that attack its own tissues due to an exaggerated immune response to the body's own tissues and materials simultaneously. Conventional treatment of autoimmune diseases are NSAIDs, glucocorticoids, and immunosuppressants that have not met the satisfaction of autoimmune therapy. The purpose of this study was to identify the usefulness and side effects of TGP against autoimmune diseases as a complementary therapy to low-dose basic therapy. This research method is an original research and intervention. This is an initial study with an analytical observational approach. The design is a 'single-group pretest-posttest design'. This research was conducted at RSUP Prof. dr. R.D Kandou and other private hospitals in Manado and Tomohon. The subjects of the study were autoimmune patients. The addition of TGP in this study did not have significant side effects on Hb, leukocytes, liver and kidney function, and the gastrointestinal tract. From this study, it can be concluded that there are clinically significant improvements in RA, Graves, Hashimoto, and Psoriasis, significant laboratory improvements in CRP and LED levels for all autoimmune patients, and insignificant laboratory improvements in anti-TPO, TSH, and FT4 levels for Graves and Hashimoto. In Aplastic Anemia, there is a significant improvement in the number of leukocytes and platelets. There are no side effects on the gastrointestinal tract, Hb, leukocytes, platelets, liver function, and kidneys.