Abstract
The effects of acute and chronic exercise on factors related to oxygen transport have been studied extensively. This process has led investigators to quantify the relationship between variables such as exercise mode and intensity, and red cell 2,3-bisphosphoglycerate (2,3-BPG) concentration. Anaerobic forms of exercise associated with a large blood lactate appearance and greatly elevated catecholamines initially decrease 2,3-BPG after exercise due to inhibited glycolysis, but there appears to be a delayed increase if sampling is continued into recovery. Aerobic forms of exercise have shown both increases and decreases. Therefore, whether 2,3-BPG is increased or decreased during and after exercise appears to be related to the exercise and blood sampling protocols employed. Further research involving resistance exercise protocols eliciting very high blood lactate and catecholamine concentrations may be beneficial in establishing a relationship between sympathetic stress response and the serial sampling of 2,3-BPG in the post-exercise recovery period. Also, in vitro analysis of the effects of the catecholamines, oxygen tension, lactate and adenosine may be helpful in understanding the dose-response relationship between these variables and 2,3-BPG concentration.
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