Abstract
A partially purified dextranase preparation (AD 17) from culture supernatant of a strain of Spicaria violacea was tested for the ability to inhibit the developmentof dental caries in conventional Sprague-Dawley rats which had been inoculated with one of the Streptococcus mutans strains MT6R (Bratthall's serotype c), OMZ176R (d), or MT703R (e). AD17 including in the cariogenic diet #2000 and drinking water inhibited the development of dental caries with statistical significance. Serotypes of S. mutans used in this experiment have been detected among Japanesechildren in various proportions. The results suggest a possibiity of clinical application of AD17 to human children for the purpose of caries prevention.
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