Abstract
D-Psicose is a rare sugar present in small quantities in natural products. In a previous study, we showed that D-psicose suppresses increase in plasma glucose and reduces body fat accumulation in rats. Based on acute and chronic toxicity testing in rats, D-psicose is classified as an ordinary and safe substance. Recently, we developed a high D-psicose syrup (PS) made from high fructose corn syrup (HFCS) by the alkaline isomerization method. However, the safety of PS as a food additive has not been demonstrated. In this study, we investigated the effects of 90-day feeding of PS in male Wistar rats. The rats were fed diets containing 3% D-psicose (control) or 4.3% PS for 90 days. The body weight gain and intra-abdominal adipose tissue weight did not differ between the control and PS group. The weights of the tissues did not differ between the two dietary groups. In clinical chemistry and hematological analyses, no differences were found between the control and PS groups. No gross pathological findings were evident at dietary doses of 4.3% PS. Therefore, the present study found no adverse effects of PS in rats fed a diet containing 4.3% PS for 90 days.
Highlights
D-Psicose (D-ribo-2-hexulose), a C-3 epimer of Dfructose, is a “rare sugar” present in small quantities in commercial mixtures of D-glucose and D-fructose obtained by hydrolysis of sucrose or isomerization of Dglucose [1]
Examining the effects of D-psicose on glucose and lipid metabolism, we found that D-psicose is a sweet monosaccharide that provides no energy to growing rats and leads to less intra-abdominal fat accumulation than D-glucose and Dfructose in rats [7,8]
We showed that 3% D-psicose in the diet had no adverse effects in rats
Summary
D-Psicose (D-ribo-2-hexulose), a C-3 epimer of Dfructose, is a “rare sugar” present in small quantities in commercial mixtures of D-glucose and D-fructose obtained by hydrolysis of sucrose or isomerization of Dglucose [1]. D-Psicose is present in processed cane and beet molasses [2], and is found in wheat [3], Itea plants [4], and in the antibiotic psicofranine [5]. We suggested previously that supplemental D-psicose can lower plasma glucose levels [9]. Toyoda et al [10] suggested that Dpsicose can prevent postprandial hyperglycemia by improving the translocation of glucokinase from the nucleus to the cytoplasm in the liver of diabetic rats. Dpsicose is expected to have a beneficial effect in the control of blood glucose levels in type 2 diabetes
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