The Effects of 8-Week Concurrent Training on Necdin and Insulin Levels in Obese Middle-aged Men

Abstract

Obesity per se is a major global health problem leading to an increase in morbidity and premature mortality however increasing physical activity often results in a marked weight loss. Necdin has been shown to be an important negative regulator of adipogenesis of the white adipose tissue. We hypothesized that exercise training would impact necdin synthesis inhibiting adipocity and ultimately reducing obesity. Thus, this study was conducted to determine the effects of 8-weeks concurrent training on plasma necdin levels in obese middle-aged men. Twenty three sedentary obese middle-aged men were randomly assigned to concurrent training group (CTG: n=12) or control group (CG: n=11). The subjects in concurrent training group performed endurance and resistance training on the same day (3 days a week, 60 min a session each day) for 8 weeks. At the end of the study, there were significant decreases in total body weight (up to 3.5 kg), body mass index (BMI; 1.2 kg/m2), waist hip ratio (WHR; 0.02 unit) and the fasting plasma insulin levels (up to 58%) and insulin resistance (HOMA-IR; P < 0.05) in CTG group compared with the CG group. However, there were no significant differences in the fasting plasma levels of glucose or necdin between the two groups at the end of the study. Concurrent training is a viable tool in reducing body weight. There seems to be no association between 8-weeks concurrent training-induced weight loss and the total plasma necdin levels in obese middle-aged men.