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Abstract
The effects of 5-hydroxytryptamine (5-HT) and related indole derivatives injected as i.a. bolus injections in a large dose range were studied in the cat superior cervical ganglion (SCG) by recording ganglionic and postganglionic electrical activity. 5-HT had two independent and opposite actions: a long-lasting inhibition of ganglionic transmission occurred already with extremely low doses and increased up to highest ones: both pre-and postsynaptic sites of action seem to be involved. In a medium and high dose range, the inhibitory effect was temporarily masked by a short-lasting stimulation and a depolarisation which was small when compared with that produced by nicotinic agents. The depolarization triggered a secondary hyperpolarization. The stimulant, but not the inhibitory action was very prone to tachyphylaxis.
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