Abstract
In cultures of E., coli deficient in cytidine deaminase 5-azacytidine is a weak inhibitor of total protein synthesis in spite of being extensively incorporated into RNA. Strong inhibition of protein synthesis in wild-type strains is due to 5-azauridine formed from 5-azacytidine by deamination. However, the blocking of replication of phage T4, shown previously to be due to primary inhibition of replication of phage DNA, is a function of 5-azacytidine itself.
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