Abstract
The effects of intracerebroventricular (ICV) β-carboline carboxylic acid ethyl ester (β-CCE) and its free acid on the protective effects of diazepam against leptazol- and R05-3663-induced convulsions were investigated in mice and compared with their effects on the antileptazol effect of sodium valproate, in an attempt to demonstrate a specific central effect of β-CCE on benzodiazepine function. The results show that a small dose (1 μg) of β-CCE but not its free acid (in doses up to 100 μg) was able to reverse the protective effects of diazepam against leptazol- and R05-3663-induced convulsions, whereas the effects of sodium valproate, a non-benzodiazepine anticonvulsant, could not be reversed by these β-carboline derivatives.
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