Abstract
Background: Leaves extract of Sauropus androgynous (Sa) or Moringaoleiefera(Mo) alone has been shown to increase hemoglobin level in iron deficiency anemia. The combination of the two extracts have been known to potentially have a synergistic effect on anemia. The objective of this study is to compare the anti-anemic effect of Sa, Mo alone and their combination on iron deficiency anemia in rats.
 Methods: Thirty female wistarstrain rats were randomly divided into 5 groups: normal, iron deficiency anemia, Sa, Mo and the combination of Sa and Mo. Beside the normal group, rats were fed Fe-deficient diet to induce iron-deficiency anemia. Level of hemoglobin, ferritin and plasma MDA were measured on day 8 (after induction of anemia) and day 29. Data were analyzed using One Way ANOVA followed by LSD post hoc test.
 Result: The rats fed with Fe-deficient diet for 7 days shown significantly had a lower plasma Hb and ferritin levels and higher plasma MDA levels compared to the normal group (p <0.05) After the treatment, the rats given the extracts significantly had a higher mean of Hb and Ferritin and a lower mean of MDA level compared to anemic control. The mean Hb, ferritin and MDA level of the combination group were close to normal group.
 Conclusion: The combination of the leaves extract of Sauropus androgynous or Moringaoleiefera is more effective against iron deficiency anemia compared to extract alone in rats.
 Bangladesh Journal of Medical Science Vol.18(1) 2019 p.136-140
Highlights
Anemia is still become health concern in Indonesia[1,2,3]
Induction of iron deficiency anemia in rats Thirty female wistar strain rats weighed 190-220 g were adapted for 7 days randomly divided into 5 groups: normal, iron deficiency anemia (IDA), Sauropus androgynous (Sa), Moringa oleiefera (Mo) and combination of Sauropus androgynous and Moringa oleiefera (SaMo)
Induction of AIN93 -M-MX deficiency diet for 7 days were success in making iron deficiency in anemia rats marked by decreased level of serum hemoglobin and ferritin concentration by 35% and 77% respectively compared to the normal group given standard diet
Summary
Anemia is still become health concern in Indonesia[1,2,3]. A study conducted by National Health survey (RISKESDAS) in 2013 showed that anemia in children under five years of age, pregnant women and the elderly in Indonesia were 28.1%; 37.1% and 44.2%, respectively[4]. Several studies have shown that untreated iron deficiency anemia can have a serious impact on health . The medium and high dose Fe supplementation for 4 weeks has been shown to increase in oxidative stress characterized by elevated levels of MDA in anemia-induced mice[15]. Leaves extract of Sauropus androgynous (Sa) or Moringaoleiefera(Mo) alone has been shown to increase hemoglobin level in iron deficiency anemia. The objective of this study is to compare the anti-anemic effect of Sa, Mo alone and their combination on iron deficiency anemia in rats. Conclusion: The combination of the leaves extract of Sauropus androgynous or Moringaoleiefera is more effective against iron deficiency anemia compared to extract alone in rats.
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