Abstract
To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells. Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA expression had a poorer prognosis (P < 0.0001). Besides, ApoM can partially inhibit the proliferative, migratory and invasive processes of BC cells. In vivo, the difference between ApoM-OE and NC groups was no significant. The level of vitamin D receptor (VDR) protein in MDA-MB-231 cells was increased by overexpression of ApoM (P < 0.05), while in MCF-7 cells, VDR levels decreased (P < 0.05). ApoM can partially inhibit the growth of BC cells. VDR may play a role, but is not the main pathway.
Highlights
In 2020, for the first time, breast cancer (BC) topped the list of new cancer cases in the report of global cancer burden
apolipoprotein M (ApoM) expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA expression had a poorer prognosis (P
The level of vitamin D receptor (VDR) protein in MDA-MB-231 cells was increased by overexpression of ApoM (P
Summary
In 2020, for the first time, breast cancer (BC) topped the list of new cancer cases in the report of global cancer burden. [4] The luminal subtypes that express hormone receptors represent the lowest degree of malignancy, and are present in more than 75% of BC patients.[5] Chemotherapy is the main treatment for TNBC, anti-HER2 therapy is often used for HER2+ BC patients, and endocrine therapy has become the major treatment for luminal BC patients after surgery as it is less toxic and has fewer side effects These treatments have achieved a certain curative effect and addressed some long-term problems faced by clinicians, they have resulted in new problems, such as increased drug resistance and toxicity toward organs, among others. To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells
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